Version 5.4
Mus musculus Protein: Psen2
Summary
InnateDB Protein IDBP-258827.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psen2
Protein Name presenilin 2
Synonyms Ad4h; ALG-3; Alg3; PS-2; PS2; Psnl2; STM2;
Species Mus musculus
Ensembl Protein ENSMUSP00000106733
InnateDB Gene IDBG-207109 (Psen2)
Protein Structure
UniProt Annotation
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in the liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001666 response to hypoxia
GO:0001708 cell fate specification
GO:0001756 somitogenesis
GO:0001921 positive regulation of receptor recycling
GO:0001933 negative regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002286 T cell activation involved in immune response
GO:0002573 myeloid leukocyte differentiation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006816 calcium ion transport
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007611 learning or memory
GO:0007613 memory
GO:0015031 protein transport
GO:0016485 protein processing
GO:0021904 dorsal/ventral neural tube patterning
GO:0030326 embryonic limb morphogenesis
GO:0030900 forebrain development
GO:0031333 negative regulation of protein complex assembly
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0035556 intracellular signal transduction
GO:0040011 locomotion
GO:0042640 anagen
GO:0042987 amyloid precursor protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043393 regulation of protein binding
GO:0043589 skin morphogenesis
GO:0044267 cellular protein metabolic process
GO:0048167 regulation of synaptic plasticity
GO:0048286 lung alveolus development
GO:0048538 thymus development
GO:0048854 brain morphogenesis
GO:0050435 beta-amyloid metabolic process
GO:0050820 positive regulation of coagulation
GO:0050852 T cell receptor signaling pathway
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051604 protein maturation
GO:0060048 cardiac muscle contraction
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030018 Z disc
GO:0030424 axon
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0035253 ciliary rootlet
GO:0036064 ciliary basal body
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:109284
InterPro IPR001108 Peptidase A22A, presenilin
IPR001493 Peptidase A22A, presenilin 2
IPR006639 Presenilin/signal peptide peptidase
PFAM PF01080
PRINTS PR01072
PR01074
PIRSF
SMART SM00730
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61144
PhosphoSite PhosphoSite-Q61144
TrEMBL D3Z0X1
UniProt Splice Variant
Entrez Gene 19165
UniGene Mm.406184
RefSeq
MGI ID
MGI Symbol Psen2
OMIM
CCDS
HPRD
IMGT
EMBL AC132436 AF038935 AK014706 BC010403 U49111 U57324 U57325
GenPept AAB92660 AAC52935 AAC52937 AAC53311 AAH10403 BAB29514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca