InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bdnf

Summary

InnateDB Protein

IDBP-258944.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdnf

Protein Name

brain derived neurotrophic factor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106678

InnateDB Gene

IDBG-195506 (Bdnf)

Protein Structure

UniProt Annotation

Function

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001657	ureteric bud development
GO:0001662	behavioral fear response
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007406	negative regulation of neuroblast proliferation
GO:0007411	axon guidance
GO:0007412	axon target recognition
GO:0007611	learning or memory
GO:0007623	circadian rhythm
GO:0007631	feeding behavior
GO:0008038	neuron recognition
GO:0014047	glutamate secretion
GO:0016358	dendrite development
GO:0019222	regulation of metabolic process
GO:0021675	nerve development
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042490	mechanoreceptor differentiation
GO:0042493	response to drug
GO:0042596	fear response
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0046668	regulation of retinal cell programmed cell death
GO:0048167	regulation of synaptic plasticity
GO:0048675	axon extension
GO:0048839	inner ear development
GO:0060548	negative regulation of cell death
GO:0061193	taste bud development
GO:0097484	dendrite extension

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0048471	perinuclear region of cytoplasm