InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Enah

Summary

InnateDB Protein

IDBP-258978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Enah

Protein Name

enabled homolog (Drosophila)

Synonyms

Mena; NDPP-1; Ndpp1; WBP8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106654

InnateDB Gene

IDBG-207633 (Enah)

Protein Structure

UniProt Annotation

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. {ECO:0000269PubMed:10069337, ECO:0000269PubMed:12134088, ECO:0000269PubMed:15066263, ECO:0000269PubMed:8861907}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10069337, ECO:0000269PubMed:12134088, ECO:0000269PubMed:8861907}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart and testis, lower levels in lung, skeletal muscle, kidney, pancreas and brain. Isoform 5 is expressed exclusively in the brain. Isoform 2 is expressed predominantly in brain, testis, ovary and fat. In the brain, isoforms 2 and 5 are expressed at highest levels in the hippocampus, cortex and midbrain, and at lowest levels in the striatum and cerebellum. Isoform 6 is expressed in brain and spleen. {ECO:0000269PubMed:10069337, ECO:0000269PubMed:1420303, ECO:0000269PubMed:8861907}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0006928	cellular component movement
GO:0007015	actin filament organization
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0030036	actin cytoskeleton organization
GO:0046907	intracellular transport

Cellular Component

GO:0001725	stress fiber
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0045202	synapse