Version 5.4
Mus musculus Protein: Slc5a12
Summary
InnateDB Protein IDBP-258991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc5a12
Protein Name solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106655
InnateDB Gene IDBG-195698 (Slc5a12)
Protein Structure
UniProt Annotation
Function Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate. {ECO:0000269PubMed:16104846, ECO:0000269PubMed:16873376}.
Subcellular Localization Apical cell membrane {ECO:0000269PubMed:16873376, ECO:0000269PubMed:17692818}; Multi- pass membrane protein {ECO:0000269PubMed:16873376, ECO:0000269PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with vimentin in Mueller cells.
Disease Associations
Tissue Specificity Expressed in the cortical region of the kidney corresponding to the proximal tubule. Expressed in Mueller cells of the inner retina (at protein level). Isoform 1 is expressed in the retina, kidney, small intestine and skeletal muscle. Isoform 2 is not detected in the kidney, small intestine and skeletal muscle. In the kidney, expressed predominantly in tubular epithelial cells of the cortical region and in the convoluted portions of the proximal tubule (pars convoluta). In the small intestine, its expression is highest in the proximal part and gradually decreased towards the distal end. Expressed in the neural retina. Not detected in the caecum and colon. {ECO:0000269PubMed:16104846, ECO:0000269PubMed:16873376, ECO:0000269PubMed:17591909, ECO:0000269PubMed:17692818}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID MGI:2138890
InterPro IPR001734 Sodium/solute symporter
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q49B93
PhosphoSite PhosphoSite-Q49B93
TrEMBL B9EJ03
UniProt Splice Variant
Entrez Gene 241612
UniGene Mm.277148
RefSeq NP_001171095
MGI ID
MGI Symbol Slc5a12
OMIM
CCDS CCDS50656
HPRD
IMGT
EMBL AF529222 AK144004 AK165419 AL732495 AY964639 BC121791 BC141255 BX005257 CH466519
GenPept AAI21792 AAI41256 AAQ09530 AAY32930 BAE25658 BAE38174 CAM26858 CAM26859 CAM27818 CAM27819 EDL27797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca