InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlr5

Summary

InnateDB Protein

IDBP-259068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr5

Protein Name

toll-like receptor 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106625

InnateDB Gene

IDBG-259066 (Tlr5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0007165	signal transduction
GO:0008584	male gonad development
GO:0032757	positive regulation of interleukin-8 production
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1858171

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01582
PF13676
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00255
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite