InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tlr5

Summary

InnateDB Gene

IDBG-259066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr5

Gene Name

toll-like receptor 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079164

Encoded Proteins

IDBP-259068

toll-like receptor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22434932

Tlr5 forms a dimer upon binding to bacterial flagellin. (Demonstrated in human)

PMID 22545147

Tlr5 is highly expressed in mucosal dendritic cells and Tlr5 signalling restricts regulatory T cell generation.

PMID 22863420

Tlr5 deficiency in mice leads to a transient inability to manage proteobacteria which promotes chronic gut inflammation.

PMID 24442437

Flagellin-specific IgG1 antibody response is induced through a Tlr5-, inflammasome-, and Myd88-independent pathway.

PMID 25395539

Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.

PMID 26003491

Indirect Tlr5-dependent stimulation of airway conventional dendritic cells is essential to flagellin's mucosal adjuvant activity.

InnateDB Annotation from Orthologs

Summary

PMID 15069060

[Homo sapiens] TLR5 engagement with its ligand, flagellin, results in the activation of MAP kinases (ERK1/2, JNK, and p38) and degradation of NFKBIA (I-kappa-B-alpha).

PMID 17283206

[Homo sapiens] Toll-like receptor 5 (TLR5) is the TLR activated by bacterial flagellin and TLR5 residue 268 is responsible for human and mouse discrimination between flagellin molecules.

PMID 11323673

[Homo sapiens] TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and its activation mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha (TNF) production.

PMID 11489966

[Homo sapiens] TLR5 expressed on the basolateral surface of intestinal epithelia mediates innate immune inflammatory responses to Salmonella by inducing epithelial pro-inflammatory gene expression.

PMID 12794153

[Homo sapiens] TLR5 forms heteromeric complexes with TLR4 as well as homomeric complexes. Signaling via heteromeric TLR5/TLR4 complexes is involved in the induction of macrophage nitric oxide (NO) production by Gram-negative flagellin.

PMID 22434932

[Homo sapiens] TLR5 forms a dimer upon binding to bacterial flagellin.

PMID 22545147

[Homo sapiens] TLR5 is highly expressed in mucosal dendritic cells and TLR5 signalling restricts regulatory T cell generation. (Demonstrated in mice)

PMID 22863420

[Homo sapiens] TLR5 deficiency in mice leads to a transient inability to manage proteobacteria which promotes chronic gut inflammation. (Demonstrated in mouse)

PMID 26950764

[Homo sapiens] CXCR1 regulates anti-Pseudomonas neutrophil responses through modulation of reactive oxygen species and interference with TLR5 expression.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187554:
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:182954788-182976044

Strand

Forward strand

Band

Transcripts

ENSMUST00000110997

ENSMUSP00000106625

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0007165	signal transduction
GO:0008584	male gonad development
GO:0032757	positive regulation of interleukin-8 production
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000187554

View Gene Order

ENSBTAG00000000477

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04620

Toll-like receptor signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_27215

MyD88 cascade initiated on plasma membrane pathway

REACT_9027

Toll Like Receptor 10 (TLR10) Cascade pathway

REACT_9061

Toll Like Receptor 5 (TLR5) Cascade pathway

REACT_6802

Innate Immune System pathway

REACT_6966

Toll-Like Receptors Cascades pathway

REACT_6900

Immune System pathway

KEGG

hsa05130

Pathogenic Escherichia coli infection pathway

hsa04620

Toll-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_016928

OMIM

CCDS

CCDS35815

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas