InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgef7

Summary

InnateDB Protein

IDBP-259242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef7

Protein Name

Rho guanine nucleotide exchange factor (GEF7)

Synonyms

betaPix; betaPix-b; betaPix-c; Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106534

InnateDB Gene

IDBG-132947 (Arhgef7)

Protein Structure

UniProt Annotation

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.

Disease Associations

Tissue Specificity

Seems to be expressed in the central nervous system. Isoform B, isoform C and isoform E are expressed with highest levels in brain and testis. {ECO:0000269PubMed:10860822, ECO:0000269PubMed:11266127}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0007399	nervous system development
GO:0030032	lamellipodium assembly
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0001726	ruffle
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1860493

InterPro

IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain

PFAM

PF00621
PF00018
PF14604
PF00307
PF00169
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00325
SM00326
SM00033
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt