Mus musculus Gene: Arhgef7 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-132947.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Arhgef7 | ||||||||||||||||||||||
Gene Name | Rho guanine nucleotide exchange factor (GEF7) | ||||||||||||||||||||||
Synonyms | betaPix; betaPix-b; betaPix-c; Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000031511 | ||||||||||||||||||||||
Encoded Proteins |
Rho guanine nucleotide exchange factor (GEF7)
Rho guanine nucleotide exchange factor (GEF7)
Rho guanine nucleotide exchange factor (GEF7)
Rho guanine nucleotide exchange factor (GEF7)
Rho guanine nucleotide exchange factor (GEF7)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102606:
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 8:11728105-11835219 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | A1.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
EGFR downregulation pathway
GPCR downstream signaling pathway
Disease pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Signaling by EGFR pathway
EPH-Ephrin signaling pathway
G alpha (12/13) signalling events pathway
Axon guidance pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Developmental Biology pathway
Ephrin signaling pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
Signaling by EGFR in Cancer pathway
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KEGG |
Regulation of actin cytoskeleton pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TCR pathway
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REACTOME |
NRAGE signals death through JNK pathway
EGFR downregulation pathway
Signaling by EGFR pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Ephrin signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-Ephrin signaling pathway
Disease pathway
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KEGG |
Regulation of actin cytoskeleton pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Regulation of RAC1 activity
Aurora A signaling
Internalization of ErbB1
Signaling events mediated by focal adhesion kinase
Integrin-linked kinase signaling
CDC42 signaling events
Regulation of CDC42 activity
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.244068 Mm.416624 Mm.417166 | ||||||||||||||||||||||
RefSeq | NM_001113517 NM_001113518 NM_017402 XM_006508841 XM_006508842 XM_006508843 XM_006508844 XM_006508845 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS22099 CCDS52480 CCDS52481 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||