Version 5.4
Mus musculus Protein: Pdgfa
Summary
InnateDB Protein IDBP-259275.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Pdgfa
Protein Name platelet derived growth factor, alpha
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106521
InnateDB Gene IDBG-206354 (Pdgfa)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005161 platelet-derived growth factor receptor binding
GO:0005518 collagen binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010035 response to inorganic substance
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910 regulation of smooth muscle cell migration
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0042493 response to drug
GO:0043406 positive regulation of MAP kinase activity
GO:0043588 skin development
GO:0045740 positive regulation of DNA replication
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048286 lung alveolus development
GO:0048839 inner ear development
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050919 negative chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060683 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005615 extracellular space
GO:0005902 microvillus
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:97527
InterPro IPR000072 PDGF/VEGF domain
IPR006782 Platelet-derived growth factor, N-terminal
IPR029034 Cystine-knot cytokine
PFAM PF00341
PF04692
PRINTS
PIRSF
SMART SM00141
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q99L56
UniProt Splice Variant
Entrez Gene 18590
UniGene Mm.487088
RefSeq
MGI ID
MGI Symbol Pdgfa
OMIM
CCDS CCDS19802
HPRD
IMGT
EMBL AC117698 AK142653 BC003817 CH466529
GenPept AAH03817 BAE25146 EDL19179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca