InnateDB Protein
|
IDBP-259401.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Elf1
|
Protein Name
|
E74-like factor 1
|
Synonyms
|
Elf-1; mElf-1; p70; Sts1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000106459
|
InnateDB Gene
|
IDBG-182872 (Elf1)
|
Protein Structure
|
|
Function |
Transcription factor that activates the LYN and BLK promoters. {ECO:0000250}.
|
Subcellular Localization |
Nucleus.
|
Disease Associations |
|
Tissue Specificity |
Predominantly found in hematopoietic cells. Detected in other cell types such as fibroblasts.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
7
[view]
|
Protein-DNA |
5
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
26 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0000981
|
sequence-specific DNA binding RNA polymerase II transcription factor activity
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
GO:0001817
|
regulation of cytokine production
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0006357
|
regulation of transcription from RNA polymerase II promoter
|
GO:0006366
|
transcription from RNA polymerase II promoter
|
GO:0030154
|
cell differentiation
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0050860
|
negative regulation of T cell receptor signaling pathway
|
|
Cellular Component |
|
PDB ID |
MGI:107180
|
InterPro |
IPR000418
Ets domain
IPR022084
Transcription factor Elf, N-terminal
|
PFAM |
PF00178
PF12310
|
PRINTS |
PR00454
|
PIRSF |
|
SMART |
SM00413
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q60775
|
PhosphoSite |
PhosphoSite-Q60775
|
TrEMBL |
Q3V1H4
|
UniProt Splice Variant |
|
Entrez Gene |
13709
|
UniGene |
Mm.20938
|
RefSeq |
NP_001273340
|
MGI ID |
|
MGI Symbol |
Elf1
|
OMIM |
|
CCDS |
CCDS27301
|
HPRD |
|
IMGT |
|
EMBL |
AK132456
AK142807
BC057134
CH466535
U19617
|
GenPept |
AAB17097
AAH57134
BAE21177
BAE25196
EDL35763
|
|
|