InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdac9

Summary

InnateDB Protein

IDBP-259435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac9

Protein Name

histone deacetylase 9

Synonyms

AV022454; D030072B18Rik; HD7B; HD9; Hdac7b; HDRP; Mitr; mKIAA0744;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106443

InnateDB Gene

IDBG-134566 (Hdac9)

Protein Structure

UniProt Annotation

Function

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. {ECO:0000269PubMed:11390982, ECO:0000269PubMed:12202037, ECO:0000269PubMed:15711539, ECO:0000269PubMed:16611996}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11390982, ECO:0000269PubMed:15546868, ECO:0000269PubMed:15711539}.

Disease Associations

Tissue Specificity

Expressed at high levels in heart, brain and spleen. Expressed in skeletal muscle. {ECO:0000269PubMed:11390982, ECO:0000269PubMed:15711539}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0033558	protein deacetylase activity
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007399	nervous system development
GO:0007507	heart development
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0030183	B cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0034983	peptidyl-lysine deacetylation
GO:0042113	B cell activation
GO:0045843	negative regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048742	regulation of skeletal muscle fiber development
GO:0051153	regulation of striated muscle cell differentiation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0035097	histone methyltransferase complex