InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrcam

Summary

InnateDB Protein

IDBP-259581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrcam

Protein Name

neuron-glia-CAM-related cell adhesion molecule

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106376

InnateDB Gene

IDBG-137217 (Nrcam)

Protein Structure

UniProt Annotation

Function

Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. {ECO:0000269PubMed:16039564}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030506	ankyrin binding
GO:0086080	protein binding involved in heterotypic cell-cell adhesion

Biological Process

GO:0001525	angiogenesis
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0008104	protein localization
GO:0010975	regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0019227	neuronal action potential propagation
GO:0031290	retinal ganglion cell axon guidance
GO:0034113	heterotypic cell-cell adhesion
GO:0045162	clustering of voltage-gated sodium channels

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:104750

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q810U4