InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nrcam

Summary

InnateDB Gene

IDBG-137217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrcam

Gene Name

neuron-glia-CAM-related cell adhesion molecule

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020598

Encoded Proteins

IDBP-137219

neuron-glia-CAM-related cell adhesion molecule

IDBP-259581

neuron-glia-CAM-related cell adhesion molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091129:
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:44328885-44601846

Strand

Forward strand

Band

Transcripts

ENSMUST00000020939	ENSMUSP00000020939
ENSMUST00000110748	ENSMUSP00000106376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030506	ankyrin binding
GO:0086080	protein binding involved in heterotypic cell-cell adhesion

Biological Process

GO:0001525	angiogenesis
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0008104	protein localization
GO:0010975	regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0019227	neuronal action potential propagation
GO:0031290	retinal ganglion cell axon guidance
GO:0034113	heterotypic cell-cell adhesion
GO:0045162	clustering of voltage-gated sodium channels