Version 5.4
Mus musculus Protein: Nek3
Summary
InnateDB Protein IDBP-259640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nek3
Protein Name NIMA (never in mitosis gene a)-related expressed kinase 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106358
InnateDB Gene IDBG-139892 (Nek3)
Protein Structure
UniProt Annotation
Function Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. {ECO:0000269PubMed:19509051}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19509051}. Cell projection, axon {ECO:0000269PubMed:19509051}.
Disease Associations
Tissue Specificity Brain. {ECO:0000269PubMed:19509051}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005737 cytoplasm
GO:0030424 axon
Protein Structure and Domains
PDB ID MGI:1344371
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R0A5
PhosphoSite PhosphoSite-Q9R0A5
TrEMBL
UniProt Splice Variant
Entrez Gene 23954
UniGene Mm.41413
RefSeq XP_006509174
MGI ID
MGI Symbol Nek3
OMIM
CCDS CCDS52519
HPRD
IMGT
EMBL AC117665 AF093416 AF099066
GenPept AAD16286 AAD20986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca