InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ank1

Summary

InnateDB Protein

IDBP-259720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ank1

Protein Name

ankyrin 1, erythroid

Synonyms

Ank-1; nb; pale;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106316

InnateDB Gene

IDBG-141556 (Ank1)

Protein Structure

UniProt Annotation

Function

Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.

Subcellular Localization

Isoform Er1: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. {ECO:0000250}.Isoform Mu7: Membrane {ECO:0000250}.Isoform Mu8: Sarcoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0051117	ATPase binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007165	signal transduction
GO:0010638	positive regulation of organelle organization
GO:0015672	monovalent inorganic cation transport
GO:0048821	erythrocyte development
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0014731	spectrin-associated cytoskeleton
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0030673	axolemma
GO:0030863	cortical cytoskeleton
GO:0031430	M band
GO:0042383	sarcolemma
GO:0045211	postsynaptic membrane