InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ank1

Summary

InnateDB Gene

IDBG-141556.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ank1

Gene Name

ankyrin 1, erythroid

Synonyms

Ank-1; nb; pale

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031543

Encoded Proteins

IDBP-141560

ankyrin 1, erythroid

IDBP-141564

ankyrin 1, erythroid

IDBP-259720

ankyrin 1, erythroid

IDBP-401558

ankyrin 1, erythroid

IDBP-401554

ankyrin 1, erythroid

IDBP-401556

ankyrin 1, erythroid

IDBP-401552

ankyrin 1, erythroid

IDBP-401551

ankyrin 1, erythroid

IDBP-401549

ankyrin 1, erythroid

IDBP-537073

ankyrin 1, erythroid

IDBP-540392

ankyrin 1, erythroid

IDBP-536466

ankyrin 1, erythroid

IDBP-626906

ankyrin 1, erythroid

IDBP-626907

ankyrin 1, erythroid

IDBP-626912

ankyrin 1, erythroid

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000029534:
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:22974844-23150497

Strand

Forward strand

Band

Transcripts

ENSMUST00000084038	ENSMUSP00000081051
ENSMUST00000033947	ENSMUSP00000033947
ENSMUST00000110688	ENSMUSP00000106316
ENSMUST00000117270	ENSMUSP00000113495
ENSMUST00000121802	ENSMUSP00000113571
ENSMUST00000117662	ENSMUSP00000113531
ENSMUST00000117296	ENSMUSP00000113656
ENSMUST00000118733	ENSMUSP00000112850
ENSMUST00000121075	ENSMUSP00000112966
ENSMUST00000123418	ENSMUSP00000121785
ENSMUST00000152511	ENSMUSP00000116533
ENSMUST00000135206
ENSMUST00000141784	ENSMUSP00000117966
ENSMUST00000130311
ENSMUST00000173248	ENSMUSP00000133322
ENSMUST00000173573	ENSMUSP00000133901
ENSMUST00000174435	ENSMUSP00000133668

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0051117	ATPase binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007165	signal transduction
GO:0010638	positive regulation of organelle organization
GO:0015672	monovalent inorganic cation transport
GO:0048821	erythrocyte development
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0014731	spectrin-associated cytoskeleton
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0030673	axolemma
GO:0030863	cortical cytoskeleton
GO:0031430	M band
GO:0031672	A band
GO:0042383	sarcolemma
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane