InnateDB Protein
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IDBP-259855.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppip5k1
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Protein Name
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diphosphoinositol pentakisphosphate kinase 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106256
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InnateDB Gene
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IDBG-202057 (Ppip5k1)
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Protein Structure
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Function |
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000827
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inositol-1,3,4,5,6-pentakisphosphate kinase activity
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GO:0000832
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inositol hexakisphosphate 5-kinase activity
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GO:0003993
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acid phosphatase activity
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GO:0005524
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ATP binding
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GO:0033857
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diphosphoinositol-pentakisphosphate kinase activity
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GO:0052723
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inositol hexakisphosphate 1-kinase activity
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GO:0052724
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inositol hexakisphosphate 3-kinase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443281
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InterPro |
IPR000560
Histidine phosphatase superfamily, clade-2
IPR029033
Histidine phosphatase superfamily
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PFAM |
PF00328
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A2ARP1
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PhosphoSite |
PhosphoSite-A2ARP1
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TrEMBL |
B0R0E7
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UniProt Splice Variant |
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Entrez Gene |
327655
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UniGene |
Mm.386076
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RefSeq |
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MGI ID |
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MGI Symbol |
Ppip5k1
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OMIM |
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CCDS |
CCDS16639
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HPRD |
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IMGT |
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EMBL |
AF502585
AK046696
AK078268
AK083140
AK122264
AL845466
BC065138
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GenPept |
AAH65138
AAP46293
BAC32838
BAC37198
BAC38780
BAC65546
CAM24220
CAM24221
CAM24222
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