Version 5.4
| Mus musculus Protein: Hecw1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-260107.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Hecw1 | ||||||||
| Protein Name | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | ||||||||
| Synonyms | 9330116H24Rik; AV273951; E130207I19Rik; Nedl1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000106145 | ||||||||
| InnateDB Gene | IDBG-131468 (Hecw1) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:14684739}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Predominantly expressed in neurons of the spinal cord. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2444115 | ||||||||
| InterPro |
IPR000008
C2 domain IPR000569 HECT IPR001202 WW domain |
||||||||
| PFAM |
PF00168
PF00632 PF00397 |
||||||||
| PRINTS |
PR00360
|
||||||||
| PIRSF | |||||||||
| SMART |
SM00239
SM00119 SM00456 |
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8K4P8 | ||||||||
| PhosphoSite | PhosphoSite-Q8K4P8 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 94253 | ||||||||
| UniGene | Mm.422150 | ||||||||
| RefSeq | NP_001074817 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Hecw1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS49207 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB083710 AC092710 AC154511 AC154615 AC161249 AK033922 AK047678 AK051569 AK053694 AK172932 CT025604 | ||||||||
| GenPept | BAB97389 BAC28516 BAC33122 BAC34677 BAC35477 BAD32210 | ||||||||