Version 5.4
Mus musculus Protein: Pds5b
Summary
InnateDB Protein IDBP-260167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pds5b
Protein Name PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Synonyms AI646570; Aprin; AS3; AW212954; mKIAA0979;
Species Mus musculus
Ensembl Protein ENSMUSP00000106112
InnateDB Gene IDBG-209633 (Pds5b)
Protein Structure
UniProt Annotation
Function Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:Q6TRW4}.
Disease Associations
Tissue Specificity Expressed in prostate. {ECO:0000269Ref.1}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005488 binding
Biological Process
GO:0007064 mitotic sister chromatid cohesion
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2140945
InterPro IPR016024 Armadillo-type fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4VA53
PhosphoSite PhosphoSite-Q4VA53
TrEMBL
UniProt Splice Variant
Entrez Gene 100710
UniGene Mm.473022
RefSeq
MGI ID
MGI Symbol Pds5b
OMIM
CCDS
HPRD
IMGT
EMBL AK041682 AK045159 AK048706 AK122414 AK164853 AY102267 BC096539
GenPept AAH96539 AAM52216 BAC31031 BAC32242 BAC33427 BAC65696 BAE37943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca