InnateDB Protein
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IDBP-260213.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cops2
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Protein Name
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COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)
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Synonyms
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AI315723; C85265; Csn2; Sgn2; TRIP-15; Trip15;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106090
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InnateDB Gene
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IDBG-203870 (Cops2)
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Protein Structure
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Function |
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269PubMed:11967155, ECO:0000269PubMed:12522100, ECO:0000269PubMed:12972599}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10087198}. Nucleus {ECO:0000269PubMed:10087198}.
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Disease Associations |
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Tissue Specificity |
Widely expressed in embryonic, fetal and adult tissues, except cartilage and smooth muscle. {ECO:0000269PubMed:10087198}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
86 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1330276
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InterPro |
IPR000717
Proteasome component (PCI) domain
IPR013143
PCI/PINT associated module
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PFAM |
PF01399
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PRINTS |
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PIRSF |
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SMART |
SM00088
SM00753
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TIGRFAMs |
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Modification |
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SwissProt |
P61202
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PhosphoSite |
PhosphoSite-P61202
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TrEMBL |
Q3V3N6
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UniProt Splice Variant |
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Entrez Gene |
12848
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UniGene |
Mm.470135
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RefSeq |
NP_001272442
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MGI ID |
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MGI Symbol |
Cops2
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OMIM |
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CCDS |
CCDS71133
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HPRD |
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IMGT |
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EMBL |
AF071312
AF087688
AF114236
AF114237
AF114238
AF114239
AF114240
AF114241
AF114242
AF114244
AF114245
AF114246
AF114247
AK010383
AK037757
AK084421
AK132207
BC023096
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GenPept |
AAC33899
AAC36309
AAD26162
AAH23096
BAB26900
BAC39179
BAE20520
BAE21033
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