InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Btn2a2

Summary

InnateDB Protein

IDBP-260287.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Btn2a2

Protein Name

butyrophilin, subfamily 2, member A2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106062

InnateDB Gene

IDBG-135856 (Btn2a2)

Protein Structure

UniProt Annotation

Function

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. {ECO:0000269PubMed:20208008}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed (at protein level). In the thymus, restricted to the corticomedullary junction, but not confined solely to epithelial cells (at protein level). Significant expression on naive B-cells, splenic natural killer cells, dendritic cells and peritoneal macrophages (at protein level). Negligible expression on naive T-cells up-regulated on activated T-cells (at protein level). {ECO:0000269PubMed:20208008}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0031324	negative regulation of cellular metabolic process
GO:0046007	negative regulation of activated T cell proliferation
GO:0050710	negative regulation of cytokine secretion

Cellular Component

GO:0005575	cellular_component
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:3606486

InterPro

IPR001870 B30.2/SPRY domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set
IPR018355 SPla/RYanodine receptor subgroup

PFAM

PF00622
PF13765
PF07686
PF08205

PRINTS

PR01407

PIRSF

SMART

SM00406
SM00409
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt