InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp8

Summary

InnateDB Protein

IDBP-260321.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Usp8

Protein Name

ubiquitin specific peptidase 8

Synonyms

AI574262; AW557536; mKIAA0055; Ubpy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106046

InnateDB Gene

IDBG-204237 (Usp8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007032	endosome organization
GO:0007265	Ras protein signal transduction
GO:0016579	protein deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody

Protein Structure and Domains

PDB ID

MGI:1934029

InterPro

IPR001202 WW domain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001763 Rhodanese-like domain
IPR015063 USP8 dimerisation domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00397
PF00443
PF00581
PF08969

PRINTS

PIRSF

SMART

SM00456
SM00450

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite