InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usp8

Summary

InnateDB Gene

IDBG-204237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp8

Gene Name

ubiquitin specific peptidase 8

Synonyms

AI574262; AW557536; mKIAA0055; Ubpy

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027363

Encoded Proteins

IDBP-204239

ubiquitin specific peptidase 8

IDBP-260321

ubiquitin specific peptidase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138592:
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:126707328-126759297

Strand

Forward strand

Band

Transcripts

ENSMUST00000028841	ENSMUSP00000028841
ENSMUST00000110416	ENSMUSP00000106046
ENSMUST00000138859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007032	endosome organization
GO:0007049	cell cycle
GO:0007265	Ras protein signal transduction
GO:0016579	protein deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody
GO:0031313	extrinsic component of endosome membrane