Version 5.4
Mus musculus Protein: Ncaph
Summary
InnateDB Protein IDBP-260385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncaph
Protein Name non-SMC condensin I complex, subunit H
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106017
InnateDB Gene IDBG-204577 (Ncaph)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007076 mitotic chromosome condensation
Cellular Component
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2444777
InterPro IPR022816 Condensin complex subunit 2/barren
PFAM PF05786
PRINTS
PIRSF PIRSF017126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C156
PhosphoSite PhosphoSite-Q8C156
TrEMBL
UniProt Splice Variant
Entrez Gene 215387
UniGene Mm.403934
RefSeq NP_659067
MGI ID
MGI Symbol Ncaph
OMIM
CCDS CCDS16693
HPRD
IMGT
EMBL AK028919 AK042706 BC021499 BC025060
GenPept AAH21499 AAH25060 BAC26195 BAC31339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca