InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gmnn

Summary

InnateDB Protein

IDBP-260392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gmnn

Protein Name

geminin

Synonyms

AW546347; Gem;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106011

InnateDB Gene

IDBG-138959 (Gmnn)

Protein Structure

UniProt Annotation

Function

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. {ECO:0000269PubMed:12192004, ECO:0000269PubMed:9635433}.Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic but can be relocalized to the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006275	regulation of DNA replication
GO:0006461	protein complex assembly
GO:0007049	cell cycle
GO:0008156	negative regulation of DNA replication
GO:0009887	organ morphogenesis
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated