InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gmnn

Summary

InnateDB Gene

IDBG-138959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gmnn

Gene Name

geminin

Synonyms

AW546347; Gem

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006715

Encoded Proteins

IDBP-138961

geminin

IDBP-260392

geminin

IDBP-713500

IDBP-714410

IDBP-715555

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112312:
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:24751845-24761923

Strand

Reverse strand

Band

A3.1

Transcripts

ENSMUST00000006898	ENSMUSP00000006898
ENSMUST00000110382	ENSMUSP00000106011
ENSMUST00000177253	ENSMUSP00000134986
ENSMUST00000176890	ENSMUSP00000135006
ENSMUST00000175689	ENSMUSP00000135823

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006275	regulation of DNA replication
GO:0006461	protein complex assembly
GO:0007049	cell cycle
GO:0008156	negative regulation of DNA replication
GO:0009887	organ morphogenesis
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated