Version 5.4
Mus musculus Protein: Prl
Summary
InnateDB Protein IDBP-260419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prl
Protein Name prolactin
Synonyms AV290867; Prl1a1;
Species Mus musculus
Ensembl Protein ENSMUSP00000105998
InnateDB Gene IDBG-139889 (Prl)
Protein Structure
UniProt Annotation
Function Prolactin acts primarily on the mammary gland by promoting lactation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007262 STAT protein import into nucleus
GO:0007567 parturition
GO:0007584 response to nutrient
GO:0007595 lactation
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0014070 response to organic cyclic compound
GO:0030278 regulation of ossification
GO:0030879 mammary gland development
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032870 cellular response to hormone stimulus
GO:0033555 multicellular organismal response to stress
GO:0042493 response to drug
GO:0042698 ovulation cycle
GO:0045471 response to ethanol
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID MGI:97762
InterPro IPR001400 Somatotropin hormone
IPR009079 Four-helical cytokine-like, core
PFAM PF00103
PRINTS PR00836
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06879
PhosphoSite PhosphoSite-P06879
TrEMBL Q9CPQ2
UniProt Splice Variant
Entrez Gene 19109
UniGene
RefSeq NP_035294
MGI ID
MGI Symbol Prl
OMIM
CCDS CCDS26389
HPRD
IMGT
EMBL AK017521 AK017579 AK077493 AK133736 AK133752 AK161557 AK161565 AK161619 AL591843 BC061141 CH466561 X02892 X04418
GenPept AAH61141 BAB30787 BAB30816 BAC36829 BAE21811 BAE21822 BAE36462 BAE36467 BAE36497 CAA26651 CAA28018 EDL32452

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca