Version 5.4
Mus musculus Gene: Prl
Summary
InnateDB Gene IDBG-139889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prl
Gene Name prolactin
Synonyms AV290867; Prl1a1
Species Mus musculus
Ensembl Gene ENSMUSG00000021342
Encoded Proteins
IDBP-139891
prolactin
IDBP-260419
prolactin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25049387
Pituitary hormone prolactin (Prl) constrains tumor-promoting liver inflammation by inhibiting Map3k1-dependent activation of Myc at the level of the trafasome.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:27057570-27065204
Strand Forward strand
Band A3.1
Transcripts
ENSMUST00000018061 ENSMUSP00000018061
ENSMUST00000110369 ENSMUSP00000105998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007262 STAT protein import into nucleus
GO:0007567 parturition
GO:0007584 response to nutrient
GO:0007595 lactation
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0014070 response to organic cyclic compound
GO:0030278 regulation of ossification
GO:0030879 mammary gland development
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032870 cellular response to hormone stimulus
GO:0033555 multicellular organismal response to stress
GO:0042493 response to drug
GO:0042698 ovulation cycle
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_189085
Disease pathway
REACT_198561
Prolactin receptor signaling pathway
REACT_198563
Amyloids pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001163530 NM_011164
OMIM
CCDS CCDS26389
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca