Mus musculus Protein: Dusp22
Summary
InnateDB Protein IDBP-260540.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp22
Protein Name dual specificity phosphatase 22
Synonyms JKAP; JSP1; LMW-DSP2; MKPX;
Species Mus musculus
Ensembl Protein ENSMUSP00000105939
InnateDB Gene IDBG-141692 (Dusp22)
Protein Structure
UniProt Annotation
Function Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). {ECO:0000269PubMed:11346645}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11346645}. Nucleus {ECO:0000269PubMed:11346645}.
Disease Associations
Tissue Specificity Specifically expressed in the testis. {ECO:0000269PubMed:11346645}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
Protein Structure and Domains
PDB ID MGI:1915926
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PRINTS PR01908
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q99N11
TrEMBL Z4YL33
UniProt Splice Variant
Entrez Gene 105352
UniGene Mm.400142
RefSeq
MGI ID
MGI Symbol Dusp22
OMIM
CCDS
HPRD
IMGT
EMBL AL731659 CH466561
GenPept EDL32381