Version 5.4
Mus musculus Protein: Rreb1
Summary
InnateDB Protein IDBP-260694.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rreb1
Protein Name ras responsive element binding protein 1
Synonyms 1110037N09Rik; AA414966; B930013M22Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000105866
InnateDB Gene IDBG-145333 (Rreb1)
Protein Structure
UniProt Annotation
Function Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors. {ECO:0000250, ECO:0000269PubMed:12700664}.
Subcellular Localization Nucleus speckle {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in splenic B-cells. {ECO:0000269PubMed:12700664}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:2443664
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UH06
PhosphoSite PhosphoSite-Q3UH06
TrEMBL B8JJE4
UniProt Splice Variant
Entrez Gene 68750
UniGene Mm.482689
RefSeq NP_001034277
MGI ID
MGI Symbol Rreb1
OMIM
CCDS CCDS36634
HPRD
IMGT
EMBL AC022682 AK147653 AK154980 AK171375 AY946044 BC080680 CT010477
GenPept AAH80680 AAX83010 BAE28051 BAE32969 BAE42417 CAX15920 CAX15921

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca