InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gfra4

Summary

InnateDB Protein

IDBP-260702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gfra4

Protein Name

glial cell line derived neurotrophic factor family receptor alpha 4

Synonyms

AW060733; G630015H18Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105864

InnateDB Gene

IDBG-206782 (Gfra4)

Protein Structure

UniProt Annotation

Function

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Subcellular Localization

Isoform a1: Cell membrane; Lipid-anchor, GPI-anchor.Isoform b1: Cell membrane; Lipid-anchor, GPI-anchor.Isoform a3: Secreted {ECO:0000305}.Isoform b3: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in many tissues including adrenal medulla, brain neurons, with highest levels in the cerebral cortex and hippocampus. Moderate levels found in the gut circular muscle and myenteric ganglia as well as in other peripheral ganglia, including the sensory dorsal root and trigeminal as well as superior cervical and sympathetic chain ganglia. Isoform a1, isoform a2, isoform b1 and isoform b2 are exclusively found in the thyroid, parthyroid and pituitary glands.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015026	coreceptor activity
GO:0016167	glial cell-derived neurotrophic factor receptor activity

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0030279	negative regulation of ossification
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway