Version 5.4
Mus musculus Protein: Sntb1
Summary
InnateDB Protein IDBP-260779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sntb1
Protein Name syntrophin, basic 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000105829
InnateDB Gene IDBG-141842 (Sntb1)
Protein Structure
UniProt Annotation
Function Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Subcellular Localization Cell membrane, sarcolemma {ECO:0000269PubMed:9214383}; Peripheral membrane protein {ECO:0000269PubMed:9214383}; Cytoplasmic side {ECO:0000269PubMed:9214383}. Cell junction {ECO:0000269PubMed:9214383}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9214383}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Disease Associations
Tissue Specificity Ubiquitous. Expressed at high levels in the liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0030165 PDZ domain binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0042383 sarcolemma
GO:0043234 protein complex
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:101781
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99L88
PhosphoSite PhosphoSite-Q99L88
TrEMBL
UniProt Splice Variant
Entrez Gene 20649
UniGene Mm.309425
RefSeq
MGI ID
MGI Symbol Sntb1
OMIM
CCDS
HPRD
IMGT
EMBL BC003748 U89997
GenPept AAB66697 AAH03748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca