InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snap25

Summary

InnateDB Protein

IDBP-260999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snap25

Protein Name

synaptosomal-associated protein 25

Synonyms

Bdr; GENA70; SNAP-25; sp; SUP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105725

InnateDB Gene

IDBG-207842 (Snap25)

Protein Structure

UniProt Annotation

Function

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. {ECO:0000269PubMed:16672379}.

Subcellular Localization

Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0010975	regulation of neuron projection development
GO:0016192	vesicle-mediated transport
GO:0060291	long-term synaptic potentiation
GO:0070201	regulation of establishment of protein localization

Cellular Component

GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0031083	BLOC-1 complex
GO:0031201	SNARE complex
GO:0044295	axonal growth cone
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex