InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Snap25

Summary

InnateDB Gene

IDBG-207842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snap25

Gene Name

synaptosomal-associated protein 25

Synonyms

Bdr; GENA70; SNAP-25; sp; SUP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027273

Encoded Proteins

IDBP-207844

synaptosomal-associated protein 25

IDBP-260999

synaptosomal-associated protein 25

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132639:
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:136713453-136782428

Strand

Forward strand

Band

Transcripts

ENSMUST00000028727	ENSMUSP00000028727
ENSMUST00000110098	ENSMUSP00000105725
ENSMUST00000125486

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0010975	regulation of neuron projection development
GO:0016192	vesicle-mediated transport
GO:0060291	long-term synaptic potentiation
GO:0070201	regulation of establishment of protein localization

Cellular Component

GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0031083	BLOC-1 complex
GO:0031201	SNARE complex
GO:0044295	axonal growth cone
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex