InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema4d

Summary

InnateDB Protein

IDBP-261124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema4d

Protein Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Synonyms

CD100; coll-4; Semacl2; Semaj; Semcl2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105666

InnateDB Gene

IDBG-152500 (Sema4d)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001934	positive regulation of protein phosphorylation
GO:0007162	negative regulation of cell adhesion
GO:0007275	multicellular organismal development
GO:0008360	regulation of cell shape
GO:0010693	negative regulation of alkaline phosphatase activity
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335	positive regulation of cell migration
GO:0031344	regulation of cell projection organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0043931	ossification involved in bone maturation
GO:0045668	negative regulation of osteoblast differentiation
GO:0048672	positive regulation of collateral sprouting
GO:0048814	regulation of dendrite morphogenesis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772	positive regulation of axonogenesis
GO:0070486	leukocyte aggregation
GO:0071526	semaphorin-plexin signaling pathway
GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

Cellular Component

GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:109244

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like domain
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437

PRINTS

PIRSF

SMART

SM00630
SM00408
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O09126

PhosphoSite

PhosphoSite-O09126

TrEMBL

UniProt Splice Variant

Entrez Gene

20354

UniGene

Mm.420142

RefSeq

MGI ID

MGI Symbol

Sema4d

OMIM

CCDS

CCDS26514

HPRD

IMGT

EMBL

BC049780 CH466546 U69535

GenPept

AAC52964 AAH49780 EDL41105 EDL41106 EDL41107