Version 5.4
Mus musculus Gene: Sema4d
Summary
InnateDB Gene IDBG-152500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sema4d
Gene Name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms CD100; coll-4; Semacl2; Semaj; Semcl2
Species Mus musculus
Ensembl Gene ENSMUSG00000021451
Encoded Proteins
IDBP-152502
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-261122
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
IDBP-261124
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187764:
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51701246-51793747
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000021900 ENSMUSP00000021900
ENSMUST00000110040 ENSMUSP00000105667
ENSMUST00000110039 ENSMUSP00000105666
ENSMUST00000125511
ENSMUST00000139865
ENSMUST00000138228
ENSMUST00000150662
ENSMUST00000139018
ENSMUST00000146238
ENSMUST00000146922
ENSMUST00000143396
ENSMUST00000139858
ENSMUST00000155896
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001934 positive regulation of protein phosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0007275 multicellular organismal development
GO:0008360 regulation of cell shape
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335 positive regulation of cell migration
GO:0031344 regulation of cell projection organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0043931 ossification involved in bone maturation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048672 positive regulation of collateral sprouting
GO:0048814 regulation of dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0070486 leukocyte aggregation
GO:0071526 semaphorin-plexin signaling pathway
GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187764
View Gene Order
ENSBTAG00000001941
Not yet available
Pathways
NETPATH
REACTOME
REACT_246650
Sema4D induced cell migration and growth-cone collapse pathway
REACT_261444
Axon guidance pathway
REACT_234744
Sema4D in semaphorin signaling pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_239484
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_231928
Other semaphorin interactions pathway
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.33903 Mm.404751 Mm.420142
RefSeq NM_001281880 NM_013660 XM_006516882 XM_006516883 XM_006516884 XM_006516885 XM_006516886 XM_006516887 XM_006516888 XM_006516889 XM_006516890
OMIM
CCDS CCDS26514
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca