InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gal3st1

Summary

InnateDB Protein

IDBP-261237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gal3st1

Protein Name

galactose-3-O-sulfotransferase 1

Synonyms

Cst; Gcst;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105608

InnateDB Gene

IDBG-141423 (Gal3st1)

Protein Structure

UniProt Annotation

Function

Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3-galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000269PubMed:11917099}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, testis, kidney, stomach, small intestine, liver, and lung. Not detected in heart, skeletal muscle, and spleen. {ECO:0000269PubMed:10727929}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001733	galactosylceramide sulfotransferase activity

Biological Process

GO:0006682	galactosylceramide biosynthetic process
GO:0007283	spermatogenesis
GO:0009058	biosynthetic process
GO:0009247	glycolipid biosynthetic process
GO:0042552	myelination