InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eef1d

Summary

InnateDB Protein

IDBP-261251.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eef1d

Protein Name

eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

Synonyms

EF-1-delta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105599

InnateDB Gene

IDBG-151679 (Eef1d)

Protein Structure

UniProt Annotation

Function

Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. {ECO:0000250}.Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). {ECO:0000250}.

Subcellular Localization

Isoform 2: Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003746	translation elongation factor activity
GO:0004871	signal transducer activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006414	translational elongation
GO:0007165	signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005634	nucleus
GO:0005853	eukaryotic translation elongation factor 1 complex

Protein Structure and Domains

PDB ID

MGI:1913906

InterPro

IPR014038 Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange
IPR018940 Elongation factor 1 beta central acidic region, eukaryote

PFAM

PF00736
PF10587

PRINTS

PIRSF

SMART

SM00888

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57776