InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr3c2

Summary

InnateDB Protein

IDBP-261389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr3c2

Protein Name

nuclear receptor subfamily 3, group C, member 2

Synonyms

Mlr; MR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105539

InnateDB Gene

IDBG-169158 (Nr3c2)

Protein Structure

UniProt Annotation

Function

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269PubMed:19029984}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00407, ECO:0000269PubMed:19029984}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart and kidney. {ECO:0000269PubMed:19029984}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005496	steroid binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006883	cellular sodium ion homeostasis
GO:0007588	excretion
GO:0043401	steroid hormone mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:99459

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt