Version 5.4
Mus musculus Gene: Nr3c2
Summary
InnateDB Gene IDBG-169158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr3c2
Gene Name nuclear receptor subfamily 3, group C, member 2
Synonyms Mlr; MR
Species Mus musculus
Ensembl Gene ENSMUSG00000031618
Encoded Proteins
IDBP-169160
nuclear receptor subfamily 3, group C, member 2
IDBP-261389
nuclear receptor subfamily 3, group C, member 2
IDBP-261391
nuclear receptor subfamily 3, group C, member 2
IDBP-261393
nuclear receptor subfamily 3, group C, member 2
IDBP-542090
nuclear receptor subfamily 3, group C, member 2
IDBP-542087
nuclear receptor subfamily 3, group C, member 2
IDBP-534812
nuclear receptor subfamily 3, group C, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151623:
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:76899442-77245012
Strand Forward strand
Band C1
Transcripts
ENSMUST00000034031 ENSMUSP00000034031
ENSMUST00000109913 ENSMUSP00000105539
ENSMUST00000109912 ENSMUSP00000105538
ENSMUST00000109911 ENSMUSP00000105537
ENSMUST00000143284 ENSMUSP00000122959
ENSMUST00000148106 ENSMUSP00000118222
ENSMUST00000128862 ENSMUSP00000116008
ENSMUST00000126697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005496 steroid binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006883 cellular sodium ion homeostasis
GO:0007588 excretion
GO:0043401 steroid hormone mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151623
View Gene Order
ENSBTAG00000027182
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.324393 Mm.397419
RefSeq NM_001083906 XM_006530574 XM_006530575 XM_006530576 XM_006530577
OMIM
CCDS CCDS40393
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca