InnateDB Protein
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IDBP-261959.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ahrr
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Protein Name
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aryl-hydrocarbon receptor repressor
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Synonyms
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mKIAA1234;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105268
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InnateDB Gene
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IDBG-167225 (Ahrr)
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Protein Structure
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Function |
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269PubMed:17949687, ECO:0000269PubMed:9887096}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9887096}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:9887096}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006805
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xenobiotic metabolic process
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GO:0007165
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signal transduction
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GO:0009410
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response to xenobiotic stimulus
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GO:0033235
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positive regulation of protein sumoylation
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:1333776
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InterPro |
IPR000014
PAS domain
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PFAM |
PF13188
PF13426
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PRINTS |
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PIRSF |
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SMART |
SM00091
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TIGRFAMs |
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Modification |
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SwissProt |
Q3U1U7
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PhosphoSite |
PhosphoSite-Q3U1U7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11624
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UniGene |
Mm.290446
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RefSeq |
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MGI ID |
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MGI Symbol |
Ahrr
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB015140
AC123833
AK154152
AK154761
AK155711
AK173134
BC118534
CT009486
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GenPept |
AAI18535
BAA37132
BAD32412
BAE32410
BAE32810
BAE33396
CAO77884
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