InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aktip

Summary

InnateDB Protein

IDBP-262029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aktip

Protein Name

thymoma viral proto-oncogene 1 interacting protein

Synonyms

AL023020; Fif; Ft; Ft1; Fts;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105238

InnateDB Gene

IDBG-179747 (Aktip)

Protein Structure

UniProt Annotation

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Note=Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia. {ECO:0000269PubMed:7956835}.

Tissue Specificity

Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver. {ECO:0000269PubMed:9383278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006915	apoptotic process
GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0008152	metabolic process
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0032092	positive regulation of protein binding
GO:0045022	early endosome to late endosome transport