Version 5.4
Mus musculus Gene: Aktip
Summary
InnateDB Gene IDBG-179747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aktip
Gene Name thymoma viral proto-oncogene 1 interacting protein
Synonyms AL023020; Fif; Ft; Ft1; Fts
Species Mus musculus
Ensembl Gene ENSMUSG00000031667
Encoded Proteins
IDBP-262029
thymoma viral proto-oncogene 1 interacting protein
IDBP-400790
thymoma viral proto-oncogene 1 interacting protein
IDBP-400789
thymoma viral proto-oncogene 1 interacting protein
IDBP-400791
thymoma viral proto-oncogene 1 interacting protein
IDBP-541720
thymoma viral proto-oncogene 1 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166971:
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:91112041-91134465
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000109609 ENSMUSP00000105238
ENSMUST00000120426 ENSMUSP00000113379
ENSMUST00000120349 ENSMUSP00000113769
ENSMUST00000120213 ENSMUSP00000112375
ENSMUST00000125257 ENSMUSP00000119277
ENSMUST00000153201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006915 apoptotic process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008152 metabolic process
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0032092 positive regulation of protein binding
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166971
View Gene Order
ENSBTAG00000016250
Not yet available
Cross-References
SwissProt
TrEMBL D3Z632
UniProt Splice Variant
Entrez Gene 14339
UniGene Mm.487451
RefSeq XM_006530673 NM_010241 XM_006530669 XM_006530670 XM_006530671 XM_006530672
OMIM
CCDS CCDS22519
HPRD
IMGT
MGI ID MGI:3693832
MGI Symbol Aktip
EMBL AC122441
GenPept
RNA Seq Atlas 14339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca