InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sla2

Summary

InnateDB Protein

IDBP-262128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sla2

Protein Name

Src-like-adaptor 2

Synonyms

A930009E21Rik; AI430952; SLAP-2; SLAP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105189

InnateDB Gene

IDBG-211028 (Sla2)

Protein Structure

UniProt Annotation

Function

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269PubMed:11891219, ECO:0000269PubMed:12024036}.

Subcellular Localization

Cytoplasm. Cell membrane. Cytoplasmic vesicle. Late endosome. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.

Disease Associations

Tissue Specificity

Mainly expressed in immune system. Highly expressed in spleen and thymus and expressed at intermediate levels in lung. Not expressed in liver, heart and brain. Isoform 1 is predominant in lung and spleen, while isoform 2 is predominant in thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0009967	positive regulation of signal transduction
GO:0042110	T cell activation
GO:0050849	negative regulation of calcium-mediated signaling