Version 5.4
Mus musculus Gene: Sla2
Summary
InnateDB Gene IDBG-211028.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sla2
Gene Name Src-like-adaptor 2
Synonyms A930009E21Rik; AI430952; SLAP-2; SLAP2
Species Mus musculus
Ensembl Gene ENSMUSG00000027636
Encoded Proteins
IDBP-211030
Src-like-adaptor 2
IDBP-262128
Src-like-adaptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101082:
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:156872457-156887192
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000029164 ENSMUSP00000029164
ENSMUST00000109561 ENSMUSP00000105189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0009967 positive regulation of signal transduction
GO:0042110 T cell activation
GO:0050849 negative regulation of calcium-mediated signaling
Cellular Component
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101082
View Gene Order
ENSBTAG00000040607
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt Q8R4L0
TrEMBL
UniProt Splice Variant
Entrez Gene 77799
UniGene Mm.387161
RefSeq XM_006500405 NM_029983
OMIM
CCDS CCDS38302
HPRD
IMGT
MGI ID MGI:1925049
MGI Symbol Sla2
EMBL AF287467 AF434990 AK020837 AK030877 AK088672 AK138709
GenPept AAL38196 AAL86403 BAB32223 BAC27168 BAC40495 BAE23754
RNA Seq Atlas 77799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca