Version 5.4
Homo sapiens Protein: SHBG
Summary
InnateDB Protein IDBP-26213.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHBG
Protein Name sex hormone-binding globulin
Synonyms ABP; SBP; TEBG;
Species Homo sapiens
Ensembl Protein ENSP00000369816
InnateDB Gene IDBG-26209 (SHBG)
Protein Structure
UniProt Annotation
Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Subcellular Localization Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are present in liver and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 64 [view]
Protein-Protein 64 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005497 androgen binding
GO:0005515 protein binding
Biological Process
GO:0007285 primary spermatocyte growth
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001791 Laminin G domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00054
PF02210
PRINTS
PIRSF
SMART SM00210
SM00282
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04278
PhosphoSite PhosphoSite-P04278
TrEMBL I3L1C1
UniProt Splice Variant
Entrez Gene 6462
UniGene Hs.632235
RefSeq NP_001276045
HUGO HGNC:10839
OMIM 182205
CCDS CCDS11117
HPRD 01646
IMGT
EMBL AC007421 BC069597 BC101785 BC112186 CD013955 CH471108 EU352659 EU352660 EU352661 M31651 X05403 X05792 X05885 X16349 X16350 X16351
GenPept AAC18778 AAH69597 AAI01786 AAI12187 ABY67997 ABY67998 ABY67999 CAA28987 CAA29234 CAA29309 CAA34398 CAA34399 CAA34400 EAW90149

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca