InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Src

Summary

InnateDB Protein

IDBP-262190.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Src

Protein Name

Rous sarcoma oncogene

Synonyms

AW259666; pp60c-src;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105159

InnateDB Gene

IDBG-211273 (Src)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 348 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	117 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	348 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019904	protein domain specific binding

Biological Process

GO:0006468	protein phosphorylation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030900	forebrain development
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0043393	regulation of protein binding
GO:0048477	oogenesis
GO:0060065	uterus development
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0071803	positive regulation of podosome assembly
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005886

plasma membrane

Protein Structure and Domains

PDB ID

MGI:98397

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM