InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arl2bp

Summary

InnateDB Protein

IDBP-262202.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl2bp

Protein Name

ADP-ribosylation factor-like 2 binding protein

Synonyms

1700010P10Rik; 1700027H16Rik; 6330544B05Rik; AI482273; AI849834; BART; Bart1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105153

InnateDB Gene

IDBG-182520 (Arl2bp)

Protein Structure

UniProt Annotation

Function

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23849777}. Mitochondrion intermembrane space {ECO:0000269PubMed:23849777}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:23849777}. Note=Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, with most abundant activity in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, retina, spleen, muscle and heart (at protein level). {ECO:0000269PubMed:10488091, ECO:0000269PubMed:11809823, ECO:0000269PubMed:18234692, ECO:0000269PubMed:23849777}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding

Biological Process

GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0050790	regulation of catalytic activity
GO:0051457	maintenance of protein location in nucleus
GO:2001141	regulation of RNA biosynthetic process