Version 5.4
Mus musculus Protein: Pus10
Summary
InnateDB Protein IDBP-262206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pus10
Protein Name pseudouridylate synthase 10
Synonyms 2810013G11Rik; 4933435A13Rik; AU014648; C77560; Ccdc139;
Species Mus musculus
Ensembl Protein ENSMUSP00000105151
InnateDB Gene IDBG-155506 (Pus10)
Protein Structure
UniProt Annotation
Function Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (By similarity). {ECO:0000250, ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0008033 tRNA processing
GO:0008150 biological_process
GO:0009451 RNA modification
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1921717
InterPro IPR020103 Pseudouridine synthase, catalytic domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D3U0
PhosphoSite PhosphoSite-Q9D3U0
TrEMBL B0QZU5
UniProt Splice Variant
Entrez Gene 74467
UniGene Mm.29536
RefSeq NP_083232
MGI ID
MGI Symbol Pus10
OMIM
CCDS CCDS24479
HPRD
IMGT
EMBL AK012737 AK017063 AK028368 AK029866 AK088562 AK145055 AL672049 AL805916 BC025555 BX255874
GenPept AAH25555 BAB28439 BAB30576 BAC25908 BAC26650 BAC40426 BAE26208 CAI24204 CAI26149 CAM16949

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca