InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP51A1

Summary

InnateDB Protein

IDBP-26221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP51A1

Protein Name

cytochrome P450, family 51, subfamily A, polypeptide 1

Synonyms

CP51; CYP51; CYPL1; LDM; P450-14DM; P450L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000003100

InnateDB Gene

IDBG-26219 (CYP51A1)

Protein Structure

UniProt Annotation

Function

Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269PubMed:20149798}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. {ECO:0000269PubMed:8619637}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	2 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008398	sterol 14-demethylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0016125	sterol metabolic process
GO:0033488	cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070988	demethylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle